Three-Dimensional Heart

Professor Florence Sheehan's Cardiovascular Research and Training Center at the University of Washington (CVRTC) has developed software packages that create three-dimensional (3D) reconstructions of the chambers and valves of the in vivo human heart derived from analysis of 3D echocardiographic images.

Three-Dimensional Heart software is available for academic and nonprofit research use at no cost from Ventripoint. Use is permitted solely for research or education (non-commercial) purposes and associated research may not be funded by any for-profit entity. Academic and nonprofit research hospitals may license the software to conduct their own analysis or analyze their own images (reviewing images and manually tracing the borders of the cardiac structures) and have the CVRTC perform three-dimensional reconstruction of heart chambers from surface landmark data using the piecewise smooth subdivision method (FullFit) as availability permits. A small service fee will be charged for the CVRTC analysis. read more

Three-Dimensional Heart Software

CatalogFit software estimates the three dimensional (3D) surface of the right ventricular endocardium from sparse input data. It provides a quick estimate of the surface of a heart chamber for the purpose of measuring its volume only. The input data required are the x,y,z coordinates of points on the right ventricle (RV) manually traced from images obtained in multiple views or planes. CatalogFit uses a database of RV surfaces reconstructed the piecewise smooth subdivision surface method of the expected variations in RV size and shape to estimate the surface given the input data. The abilitiy to estimate the RB of a new patient requires a catalog embodying expected variations in RB shape for that patient’s diagnosis.

Tracking software and procedures for calibrating a magnetic field tracking system, testing for the presence of ferro-magnetic interference in the environment, and for acquiring a three dimensional echocardiographic dataset.

User interface software is used for reviewing images, selecting the end diastolic and end systolic frames, manually tracing heart borders, editing traced borders, displaying 3D surface reconstructions, and displaying mesh generated heart borders on the images.

FullFit software performs three dimensional reconstruction of heart chambers producing the three dimensional surface of the heart and its volume. FullFit uses the piecewise smooth subdivision surface method, the only method shown to provide anatomically accurate three dimensional shape representation. Models are available for the left ventricle, right ventricle, right atrium, and left atrium. Data from any imaging modality can be input. The input required for the left ventricle consists of at least five well distributed left ventricular borders, twenty five well distributed points on the mitral annulus, three points on the mitral annulus, three points around the aortic valve, and one point on the left ventricular apex. A license to MatLab is required to operate FullFit. FullFit employs methods covered by US Patent 5,889,524.

Once the Fullfit surface has been generated, analysis of the mitral valve shape (MitralApp software), the left ventricle shape (Center Axis software), and/or the left ventricle function (CenterSurface) can be conducted.

MitralApp

3D surface reconstructions of normal and dilated left ventricles, displaying the mitral and aortic valve annuli, the papillary muscles, and chordae tendineae.

MitralApp software analyzes the dimensions of mitral annulus components and their relative geometry from 3D data. Parameters of the mitral annulus include annular area, perimeter length, eccentricity, height, motion, peak-to-peak span, and valley-to-valley span. Parameters of the papillary muscles include location and length. Parameters of the chordae include length, angle to the annulus plane, and interchordal angle. The input to the software is the x, y, and z coordinates of at least 25 points on, and distributed evenly around, the mitral annulus.

CenterSurface

CenterSurface software measures regional wall thickness from 3D reconstructions of the left ventricular endocardial and epicardial surfaces, for use in computing regional wall thickening as a parameter of ventricular function. The algorithm computes a medial surface (CenterSurface) midway between the two input surfaces, and then constructs chords orthogonal to the CenterSurface. The length of each chord when extended to its intersections with the input surfaces is the measure of local orthogonal wall thickness. The method can also be used to measure local distance between two 3D surfaces, to analyze motion over time or difference in 3D shape. The input to the software is two 3D surfaces of the same chamber of the same person's heart, generated using FullFit.

Cutaway view of reconstructions of the LV endocardium and epicardium and the CenterSurface (arrow).

Center Axis

Regional left ventricular shape analysis by the center axis method.

For more information: http://depts.washington.edu/cvrtc/

Licensing Information

Three-Dimensional Heart is one of the many software programs and tools created at the University of Washington available through our Express Licensing Program. These agreements have standard terms and conditions that allow for rapid licensing by companies, organizations, or individuals

Academic License

Available to academic and nonprofit researchers at no cost from Ventripoint. Three Dimensional Heart Software use is permitted solely for research or education (non-commercial) purposes and associated research may not be funded by any for-profit entity. One agreement is used to license CatalogFit, FullFit, User Interface, or Tracking software and is available from Ventripoint.

MitralApp, CenterAxis, and FullFit also require MATLAB® mathematical modeling software, which you can purchase separately from The MathWorks, Inc. store.

The conditions and financial terms of this license apply only to those who download the license, sign it and return it "as is" to the UW Center for Commercialization. Some Express Licenses may be modified for an additional cost. Other licensing arrangements may be available.

For Descriptive and Technical Information

Florence Sheehan, MD
University of Washington
Cardiovascular Research and Training Center
Seattle, WA 98195

Email: 

For Licensing Information/Customer Service

Express Licensing Program
UW Center for Commercialization
4311 11th Avenue NE, Suite 500
Seattle, WA 98105-4608
Phone: (206) 543-3970
Fax: (206) 616-3322
Email: license@u.washington.edu